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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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p-{3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinylmethyl}cinnamic Acid → p-{3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinylmethyl}hydrocinnamic Acid

HRID 443672
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HRID 443672 반응식
[OH:1][C:2]1([CH2:8][CH2:9][N:10]2[C:14](=[O:15])[CH2:13][S:12][CH:11]2[CH2:16][C:17]2[CH:27]=[CH:26][C:20]([CH:21]=[CH:22][C:23]([OH:25])=[O:24])=[CH:19][CH:18]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[H][H]>C(O)C.[Pd]>[OH:1][C:2]1([CH2:8][CH2:9][N:10]2[C:14](=[O:15])[CH2:13][S:12][CH:11]2[CH2:16][C:17]2[CH:27]=[CH:26][C:20]([CH2:21][CH2:22][C:23]([OH:25])=[O:24])=[CH:19][CH:18]=2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1
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참가 물질

5

반응물 2

HCID 53980169p-{3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinylmethyl}cinnamic AcidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 23468090p-{3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinylmethyl}hydrocinnamic Acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

p-{3-[2-(1-Hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinylmethyl}cinnamic Acid (7.8 g., 0.02 mole) in ethanol (125 ml.) is hydrogenated over 2.5 g. of a 5% Pd on charcoal catalyst at 1 atmosphere pressure and 27° C. When the theoretical amount (0.02 mole) of hydrogen has been absorbed, the catalyst is filtered off, the solvent evaporated, and the residue chromatographed on silica gel with 4% methanol in chloroform as the eluant. The title compound is obtained as a colorless, viscous oil.

후처리

  1. customat 1 atmosphere pressure and 27° C
  2. filtrationthe catalyst is filtered off
  3. customthe solvent evaporated
  4. customthe residue chromatographed on silica gel with 4% methanol in chloroform as the eluant

출처 및 근거

ORD 기록
ord-32aae5cb8498426daaa11357b945a5ca
출처 데이터셋
uspto-grants-1981_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04260771

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