Bromine → HCID 178447937, 화합물
반응식
[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10]O)[CH2:6][CH2:5]1)[CH2:2][CH3:3].[Br:12]Br>CCOCC>[CH2:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][Br:12])[CH2:6][CH2:5]1)[CH2:2][CH3:3]참가 물질
4
반응 조건
- 온도
- 180 °C
실험 절차
Trans-4-n-propylcyclohexylmethanol (0.12 mole) was added to red phosphorus (0.03 g atom) and warmed gently (ca 30° C.) using an oil bath. Bromine (0.14 mole) was added dropwise to the mixture. When addition was complete (about 1/2 hour) the temperature of the oil bath was raised to 180° C. for one hour. After this time, the mixture was allowed to cool, shaken with ether and filtered. The filtrate was washed with water, then dried (Na2SO4). The ether was removed by distillation and the residue distilled. The product boiled at 112° C. at a pressure of 15 mm Hg.
후처리
- temperaturewarmed gently (ca 30° C.)
- additionWhen addition
- custom(about 1/2 hour)
- temperatureto cool
- filtrationfiltered
- washThe filtrate was washed with water
- dry with materialdried (Na2SO4)
- customThe ether was removed by distillation
- distillationthe residue distilled
출처 및 근거
- ORD 기록
- ord-0f2f611d56674162869859c0568871e5
- 출처 데이터셋
- uspto-grants-1981_04
- 특허 번호
- US04261651
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