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Water → N-(1,3-thiazol-2-yl)-4-nitro-2-trichloromethylphenylsulfenamide

HRID 443774
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인쇄 미리보기

반응식

HRID 443774 반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[N+:7]([C:10]1[CH:15]=[CH:14][C:13]([S:16]Cl)=[C:12]([C:18]([Cl:21])([Cl:20])[Cl:19])[CH:11]=1)([O-:9])=[O:8].O>O1CCCC1>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[NH:1][S:16][C:13]1[CH:14]=[CH:15][C:10]([N+:7]([O-:9])=[O:8])=[CH:11][C:12]=1[C:18]([Cl:19])([Cl:20])[Cl:21]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 962WaterHCID 21552-AminothiazoleHCID 127635554-Nitro-2-trichloromethylbenzenesulfenyl chloride

생성물 1

HCID 23465398N-(1,3-thiazol-2-yl)-4-nitro-2-trichloromethylphenylsulfenamide수율 70%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
10 °C

실험 절차

40 g of 2-aminothiazole is dissolved in 500 ml of tetrahydrofuran; while stirring and at 10° C., 61.4 g of 4-nitro-2-trichloromethylbenzenesulfenyl chloride is added. The addition of water precipitates the sulfenamide, which is filtered and recrystallized from ethyl acetate. There is obtained 50 g (70% of theory) of N-(1,3-thiazol-2-yl)-4-nitro-2-trichloromethylphenylsulfenamide; m.p.: 165° C.

후처리

  1. customprecipitates the sulfenamide, which
  2. filtrationis filtered
  3. customrecrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-8639666210024c48959d2c2918f0497a
출처 데이터셋
uspto-grants-1981_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04261924

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