Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylmorpholine → Boc-(D)Ala-Gly-OBzl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylmorpholine | HCID 7525 | — |
| 반응물 | Isobutyl chloroformate | HCID 62365 | — |
| 반응물 | BOC-D-alanine | HCID 637606 | — |
| 반응물 | HCID 124082031 | HCID 124082031 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Boc-(D)Ala-Gly-OBzl | HCID 15567200 | — |
반응 단계
1.9 g of Boc-(D)Ala-OH and 1.3 ml of N-ethylmorpholine are dissolved in 50 ml of absolute tetrahydrofuran and 1.3 ml of chloroformic acid iso-butyl ester added dropwise at a temperature of -15°. After 5 minutes, a solution of 3.4 g of glycine-benzylester-tosylate and 1.3 ml of N-ethylmorpholine in 50 ml of DMF is added. After 1 hour's stirring at -10°, the reaction mixture is evaporated and the residue taken up in acetic acid. The solution is repeatedly washed with dilute citric acid and potassium bicarbonate. The title compound is crystallised from ether. M.P. 88°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04261888 |
| 출처 데이터셋 | uspto-grants-1981_04 |
| ORD ID | ord-5f2e5740709f4fb6bfb0199f9648dad8 |
| 출처 메모 | uspto-grants-1981_04 |