Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Butanol → Boc-N-Me-Phe-OH
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Butanol | HCID 263 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N-Methylphenylalanine | HCID 6951135 | — |
| 반응물 | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Boc-N-Me-Phe-OH | HCID 7010602 | — |
반응 단계
3.6 g of H-MePhe-OH are dissolved in a mixture of ter.-butanol, 25 ml of 10% aqueous KHCO3 solution and 5 ml of 4 N sodium hydroxide. 8 ml of di-tert.-butylcarbonate are added and the mixture stirred for 2 days at room temperature. The reaction mixture is diluted with ca. 100 ml of water and extracted with ether. The aqueous phase is acidified, with stirring to pH 2. The precipitated product is extracted with acetic acid, the extract washed with water and dried over Na2SO4. The liquid is evaporated and the product crystallised from ether/petroleum ether to yield Boc-MePHe-OH. M.P. 87°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04261888 |
| 출처 데이터셋 | uspto-grants-1981_04 |
| ORD ID | ord-96ee78c924034d5a92685256586e1f57 |
| 출처 메모 | uspto-grants-1981_04 |