Tributylstannane → HCID 23466037, 화합물

HRID 443930노트

반응식

HRID 443930 반응식
[OH:1][C:2]1([CH3:18])[CH:8](Br)[CH:7]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:6][C:4](=[O:5])[CH2:3]1.C([SnH](CCCC)CCCC)CCC>O1CCCC1>[OH:1][C:2]1([CH3:18])[CH2:8][CH:7]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[O:6][C:4](=[O:5])[CH2:3]1

참가 물질

4

반응물 2

HCID 5948TributylstannaneHCID 12878303HCID 12878303, 화합물

생성물 1

HCID 23466037HCID 23466037, 화합물수율 54.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 200 mg of 3-hydroxy-3-methyl-4-bromo-7-phenyl-5-heptanolide in 2 ml of anhydrous tetrahydrofuran was added 500 mg of tri-n-butyltin hydride and the mixture was allowed to stand overnight at room temperature. After completion of the reaction, tetrahydrofuran was evaporated and n-hexane was added to the residue to precipitate an oily substance, which was purified by a thin layer chromatography (silica gel) affording 82 mg of the desired compound.

후처리

  1. customwas evaporated
  2. additionn-hexane was added to the residue
  3. customto precipitate an oily substance, which
  4. customwas purified by a thin layer chromatography (silica gel)

출처 및 근거

ORD 기록
ord-2116832985e841d2aea5c4a7caafd541
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04262013

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