O-Phenylenediamine → methyl 2-(3-oxo-4H-quinoxalin-2-yl)acetate

HRID 443982노트

반응식

HRID 443982 반응식
[C:1]([C:7]([O:9][CH3:10])=[O:8])#[C:2][C:3](OC)=[O:4].[C:11]1([NH2:18])[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[NH2:17]>CO>[O:4]=[C:3]1[NH:18][C:11]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:17]=[C:2]1[CH2:1][C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 2

HCID 7243O-PhenylenediamineHCID 12980Dimethyl acetylenedicarboxylate

생성물 1

HCID 310826methyl 2-(3-oxo-4H-quinoxalin-2-yl)acetate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Dimethyl acetylenedicarboxylate (31.2 g., 0.22 mol.) was added slowly to a solution of o-phenylenediamine (21.6 g., 0.2 mol.) in methanol (400 ml.). The reaction mixture was stirred at room temperature for three hours and then cooled in an ice bath. The yellow solid was collected and washed with cold methanol. The solid was recrystallized from tetrahydrofuran (27.7 g., m.p. 230°-232° dec.).

후처리

  1. temperaturecooled in an ice bath
  2. customThe yellow solid was collected
  3. washwashed with cold methanol
  4. customThe solid was recrystallized from tetrahydrofuran (27.7 g., m.p. 230°-232° dec.)

출처 및 근거

ORD 기록
ord-15539353f62c486bb1da964ee7c3b411
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04262123

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