(3-Mercaptopropyl)ammonium chloride → HCID 178479415, 화합물

HRID 444002

반응식

HRID 444002 반응식
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][SH:6].[O-]CC.[Na+].Cl.[NH:12]([C:16]1[S:17][CH:18]=[C:19]([CH2:21][Cl:22])[N:20]=1)[C:13]([NH2:15])=[NH:14]>C(O)C>[ClH:22].[NH:12]([C:16]1[S:17][CH:18]=[C:19]([CH2:21][S:6][CH2:5][CH2:4][CH2:3][NH2:2])[N:20]=1)[C:13]([NH2:15])=[NH:14]

참가 물질

5

반응물 3

HCID 197870(3-Mercaptopropyl)ammonium chlorideHCID 2723922Sodium ethoxideHCID 178479412HCID 178479412, 화합물

생성물 1

HCID 178479415HCID 178479415, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

반응 조건

온도
0 °C

실험 절차

3-Aminopropanethiol hydrochloride (2.54 g.) in ethanol (20 ml.) was added to a solution of sodium ethoxide (1 g. Na in 25 ml. ethanol) at 0° C. under a nitrogen atmosphere. The suspension was stirred at 0° C. for 2 hours and a solution of 2-guanidino-4-chloromethylthiazole hydrochloride (2.27 g.) in ethanol (25 ml.) was then added. The suspension was allowed to reach room temperature and stirred for 16 hours. Filtration of the suspension and acidification of the filtrate with concentrated hydrochloric acid gave a precipitate of 2-guanidino-4-[(3-aminopropyl)thiomethyl]thiazole hydrochloride, m.p. >350° C.

후처리

  1. customto reach room temperature
  2. stirringstirred for 16 hours
  3. filtrationFiltration of the suspension and acidification of the filtrate with concentrated hydrochloric acid

출처 및 근거

ORD 기록
ord-2eaa7a1c3b8a4f88928dbeab9b9a7f6d
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04262126

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