Chlorosuccinimide → 2-(2-Methoxy-5-bromophenyl)-2-methyl-1-chloropropyl methyl sulphide

HRID 444077

반응식

HRID 444077 반응식
[Cl:1]N1C(=O)CCC1=O.[CH3:9][S:10][CH2:11][C:12]([C:15]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])([CH3:14])[CH3:13]>C(Cl)(Cl)(Cl)Cl>[CH3:9][S:10][CH:11]([Cl:1])[C:12]([C:15]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])([CH3:14])[CH3:13]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 205362252-(2-Methoxy-5-bromophenyl)-2-methyl-1-propyl methyl sulphide

생성물 1

HCID 205362412-(2-Methoxy-5-bromophenyl)-2-methyl-1-chloropropyl methyl sulphide수율 99%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
40 °C

실험 절차

N-Chlorosuccinimide (37.4 g, 0.28 mole) was added portionwise to 2-(2-methoxy-5-bromophenyl)-2-methyl-1-propyl methyl sulphide (79.3 g, 0.275 mole) in carbon tetrachloride (250 ml) at room temperature. An exothermic reaction ensued, the temperature being allowed to rise to 40° C. before control with an external cooling bath was applied. After addition, the reaction mixture was heated at about 40° C. for 4 hours, then cooled, filtered and run down yielding 88 g crude title product (99%).

후처리

  1. customAn exothermic reaction
  2. customto rise to 40° C. before control with an external cooling bath
  3. additionAfter addition
  4. temperaturecooled
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-45337b4c9852467493ce747f1f2ef810
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263037

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