Dimethylformamide → 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran

HRID 444082노트

반응식

HRID 444082 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7]([CH3:11])([CH3:10])[C:6]=2[CH:12]=1.[CH3:13][N:14](C)C=O>>[C:13]([C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7]([CH3:11])([CH3:10])[C:6]=2[CH:12]=1)#[N:14]

참가 물질

3

반응물 2

HCID 6228DimethylformamideHCID 53235955-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran

생성물 1

HCID 205361905-Cyano-2,3-dihydro-3,3-dimethylbenzofuran

실험 절차

5-Bromo-2,3-dihydro-3,3-dimethylbenzofuran (15 g, 0.066 mole) was heated under reflux with cuprous cyanide (7.2 g. 0.08 mole) in dimethyl formamide (15 ml) as in Example 2. Work up yielded, after recrystallisation from petroleum ether (bp 60°-80° C.) with charcoaling, 5.7 g of product, mp 72°-75° C.

후처리

  1. customWork up yielded
  2. customafter recrystallisation from petroleum ether (bp 60°-80° C.) with charcoaling, 5.7 g of product, mp 72°-75° C.

출처 및 근거

ORD 기록
ord-ad44c049a2b543cba4bb3fed2272fe36
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263037

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