Morpholine → 5-Cyano-2-morpholino-2,3-dihydro-3,3-dimethylbenzofuran
반응식
Cl[CH:2]1[C:6]([CH3:8])([CH3:7])[C:5]2[CH:9]=[C:10]([C:13]#[N:14])[CH:11]=[CH:12][C:4]=2[O:3]1.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>>[C:13]([C:10]1[CH:11]=[CH:12][C:4]2[O:3][CH:2]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[C:6]([CH3:8])([CH3:7])[C:5]=2[CH:9]=1)#[N:14]참가 물질
3
실험 절차
2-Chloro-5-cyano-2,3-dihydro-3,3-dimethylbenzofuran (4.1 g), prepared as in Example 45 was heated under reflux at about 130° C. in morpholine (20 ml) for 4 hours. Addition to ice-water, followed by extraction with diethyl ether, gave, after water washing, drying over sodium sulphate and running down, 3.3 g of crude title product. Recrystallisation from isopropanol gave 2.3 g of pure product, mp 105°-107° C.
후처리
- temperaturewas heated
- extractionfollowed by extraction with diethyl ether
- customgave
- dry with materialafter water washing, drying over sodium sulphate
- customRecrystallisation from isopropanol
출처 및 근거
- ORD 기록
- ord-04a7ba76c08c4c7cac7b118d482b41c3
- 출처 데이터셋
- uspto-grants-1981_04
- 특허 번호
- US04263037
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