2-Iodobenzoic acid → 4-Amino-3-(o-carboxyphenylthio)benzoic Acid

HRID 444155노트

반응식

HRID 444155 반응식
[SH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH2:11])[C:5]([OH:7])=[O:6].I[C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]>[Cu]>[NH2:11][C:10]1[CH:9]=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=1[S:1][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]

참가 물질

4

반응물 2

HCID 69412-Iodobenzoic acidHCID 5980584-Amino-3-mercaptobenzoic acid

생성물 1

HCID 234644884-Amino-3-(o-carboxyphenylthio)benzoic Acid

시약·촉매·용매 1

HCID 23978Copper촉매

실험 절차

Reflux a mixture of 200 ml of the 50% potassium hydroxide solution of Step A, 24.15 gm (97 mmoles) of o-iodobenzoic acid and 7.5 gm of copper metal powder for 11/2 hours. Cool the mixture and filter. Dilute the filtrate to twice its volume with water and acidify. Separate the solids by filtration, wash well with water and air dry.

후처리

  1. temperatureReflux
  2. temperatureCool the mixture
  3. filtrationfilter
  4. additionDilute the filtrate to twice its volume with water
  5. customSeparate the solids
  6. filtrationby filtration
  7. washwash well with water and air
  8. customdry

출처 및 근거

ORD 기록
ord-729869e585f3488ea62039d0517b3713
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04263207

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