Tetrahydrofuran → HCID 13013940, 화합물

반응식

[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:13]=[C:14]([C:17]([OH:19])=[O:18])[CH:15]=[CH:16][C:4]=2[NH:3]1.O1CCC[CH2:21]1>>[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:13]=[C:14]([C:17]([O:19][CH3:21])=[O:18])[CH:15]=[CH:16][C:4]=2[NH:3]1

참가 물질

반응물 2

HCID 8028Tetrahydrofuran

HCID 13013939HCID 13013939, 화합물

생성물 1

HCID 13013940HCID 13013940, 화합물

실험 절차

Dissolve 1 gm of the acid of Example 22 with heating in 100 ml of tetrahydrofuran. Filter and cool the filtrate to room temperature. Add 500 mg. of diazomethane and stir at room temperature for 30 minutes. Strip to dryness and triturate the residue in methanol. Recover the title product by filtration. (m.p. 240°-257° C.).

후처리

filtrationFilter
additionAdd 500 mg
customStrip to dryness and triturate the residue in methanol
customRecover the title product
filtrationby filtration

출처 및 근거

ORD 기록: ord-6b27b553b41646a29e28edd664413267
출처 데이터셋: uspto-grants-1981_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04263207

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