Thionyl Chloride → 3-Chlorocarbonyl-10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin
반응식
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][C:11]([C:13](O)=[O:14])=[CH:12][C:7]=2[S:6][C:5]2[CH:16]=[CH:17][CH:18]=[CH:19][C:4]=2[NH:3]1.S(Cl)([Cl:22])=O>>[Cl:22][C:13]([C:11]1[CH:10]=[CH:9][C:8]2[C:2](=[O:1])[NH:3][C:4]3[CH:19]=[CH:18][CH:17]=[CH:16][C:5]=3[S:6][C:7]=2[CH:12]=1)=[O:14]참가 물질
3
실험 절차
Heat a solution of 5 gm. of 10,11-dihydro-11-oxodibenzo[b,f][1,4]thiazepin-3-carboxylic acid and 40 ml of thionyl chloride under reflux for 20 minutes. Evaporate the reaction mixture under vacuum to dryness. Repeat the evaporation with two 30 ml portions of carbon tetrachloride. Crystallize the residue from diisopropyl ether to obtain the title product.
후처리
- temperatureHeat a solution of 5 gm
- customEvaporate the reaction mixture under vacuum to dryness
- customRepeat the evaporation with two 30 ml portions of carbon tetrachloride
- customCrystallize the residue from diisopropyl ether
출처 및 근거
- ORD 기록
- ord-2cef2ca99cde451ca11b0dedbf9439f3
- 출처 데이터셋
- uspto-grants-1981_04
- 특허 번호
- US04263207
반응 노트
불러오는 중…