Acetone → HCID 86737701, 화합물

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C[C:2]1[CH:11]=[CH:10][C:5]([C:6](=[O:9])[CH2:7]Br)=[CH:4][CH:3]=1.O.O.[N+:14]([C:17]1[CH:22]=[CH:21][C:20]([O-:23])=[CH:19][CH:18]=1)([O-:16])=[O:15].[Na+].[CH3:25]C(C)=O>>[CH3:25][C:17]1([N+:14]([O-:16])=[O:15])[CH:22]=[CH:21][C:20]([O:23][CH2:7][C:6]([C:5]2[CH:4]=[CH:3][CH:2]=[CH:11][CH:10]=2)=[O:9])=[CH:19][CH2:18]1

참가 물질

반응물 3

HCID 180Acetone

HCID 692722-Bromo-4'-methylacetophenone

HCID 2735104Sodium 4-nitrophenolate dihydrate

생성물 1

HCID 86737701HCID 86737701, 화합물수율 78.9%

실험 절차

4-Methylphenacyl chloride (XVI: X=Cl) (37.8 g, 0.224 mole) and sodium 4-nitrophenolate (XI) (38.6 g, 0.24 mole) were added to acetone (300 ml), and the mixture was heated under reflux for 10 hours. Thereafter, the reaction mixture was treated in the same manner as in Example 29 to obtain 47.9 g of 4-methyl-α-(4-nitrophenoxy)acetophenone (XII) (yield, 78.9%).

후처리

temperaturethe mixture was heated
temperatureunder reflux for 10 hours
additionThereafter, the reaction mixture was treated in the same manner as in Example 29

출처 및 근거

ORD 기록: ord-e154d898655b47cb8e2c2b9cfcd36a44
출처 데이터셋: uspto-grants-1981_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04263219

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