Trifluoroacetic acid → 4-(2-Aminoethyl)benzonitrile

HRID 44419노트

반응식

HRID 44419 반응식
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[CH:5][CH:4]=1)#[N:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH2:11])=[CH:5][CH:4]=1)#[N:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 21955533tert-Butyl 4-cyanophenethylcarbamate

생성물 1

HCID 219125254-(2-Aminoethyl)benzonitrile수율 95.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Compound 114 (308 mg, 1.25 mmol) was dissolved in DCM (4 mL) and the solution was cooled in an ice-water bath. TFA (3.5 mL) was then added and the mixture was stirred at room temperature for 15 min. The reaction mixture was concentrated in vacuo and the residue was dissolved in EtOAc (50 mL). The solution was washed with K2CO3 (sat., 3×), brine, dried and concentrated to yield 115 (175 mg, 95%) as a pale yellow oil. MS (APCI): m/z 147 [M+H]+.

후처리

  1. temperaturethe solution was cooled in an ice-water bath
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. dissolutionthe residue was dissolved in EtOAc (50 mL)
  4. washThe solution was washed with K2CO3 (sat., 3×), brine
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a766666a5cee47efaed4399655e05a4c
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541423B2

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