참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Isobutylmalonic acid | HCID 78069 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Carboxy-4-methyl-2-[(dimethylamino)methyl]pentanoic acid | HCID 13017556 | 63% |
반응 단계
2-Carboxy-4-methylpentanoic acid (67 g) is suspended in 400 ml of water and cooled to 5° C. Aqueous 40% dimethylamine (50 g) is added to the suspension followed by aqueous 37% formaldehyde (35.7 g). The resulting solution is stirred for about 16 hours and solid product is filtered and dried in vacuo to yield 57.3 g of the title compound, melting point 134°-137° C. with carbon dioxide and dimethylamine given off.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04263293 |
|---|
| 출처 데이터셋 | uspto-grants-1981_04 |
|---|
| ORD ID | ord-1764e36943b84ecdaed90320f5ae4ed7 |
|---|
| 출처 메모 | uspto-grants-1981_04 |
|---|
