Phthalimide → N-Aminophthalimide

HRID 444386

반응식

HRID 444386 반응식
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[NH2:12]N>C(O)C>[NH2:12][N:5]1[C:1](=[O:11])[C:2]2[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4]1=[O:6]

참가 물질

4

반응물 2

HCID 6809PhthalimideHCID 9321Hydrazine

생성물 1

HCID 74645N-Aminophthalimide수율 75.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To an ice-cold suspension of 14.7 g (0.1 mole) of phthalimide in 100 ml of 95% ethyl alcohol at 5° C., with stirring, 3.6 ml (0.11 mole) of 96.8% hydrazine was added dropwise. A slight exothermic reaction was observed and the mixture was allowed to stir at 5° C. for two hours. The mixture was diluted with 200 ml of ice water, stirred, filtered, washed with water and dried to give 12.2 g (75%) of white powder, m.p. 199°-202°.

후처리

  1. customA slight exothermic reaction
  2. stirringto stir at 5° C. for two hours
  3. stirringstirred
  4. filtrationfiltered
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-278d329dd7d84b89a0140ad822e6d942
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04264502

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