Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-tert-butoxycarbonyl-2-(4-hydroxyphenyl)glycine phenacyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Phenacyl bromide | HCID 6259 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N-Boc-4-Hydroxyphenyl-DL-glycine | HCID 4189925 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-tert-butoxycarbonyl-2-(4-hydroxyphenyl)glycine phenacyl ester | HCID 20559123 | 99.6% |
반응 단계
A solution of N-tert-butoxycarbonyl-2-(4-hydroxyphenyl) glycine (9.18 g.), phenacyl bromide (6.86 g.) and sodium hydroxide (1.37 g.) in N,N-dimethylformamide (100 ml.) was stirred for 4 hours at ambient temperature. The reaction mixture was poured into water (500 ml.) and extracted three times with every 50 ml. portions of ethyl acetate. The combined extract was washed with water, dried over magnesium sulfate, and evaporated to dryness under reduced pressure to give an oily N-tert-butoxycarbonyl-2-(4-hydroxyphenyl)glycine phenacyl ester (13.19 g.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04264498 |
| 출처 데이터셋 | uspto-grants-1981_04 |
| ORD ID | ord-a0cd57081ebf4a2eb7bdb5177d46e5e6 |
| 출처 메모 | uspto-grants-1981_04 |