Chlorotrimethylsilane → 2-(2-Acetoxy-3-chloro-propoxy)-3-methoxy-pyridine
반응식
C[Si](C)(C)[Cl:3].C([O:8][C:9]1([CH3:24])O[CH2:12][CH:11]([CH2:14][O:15][C:16]2[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[CH:18][N:17]=2)[O:10]1)C>C(Cl)Cl>[C:9]([O:10][CH:11]([CH2:12][Cl:3])[CH2:14][O:15][C:16]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[CH:18][N:17]=1)(=[O:8])[CH3:24]참가 물질
4
실험 절차
45 ml of trimethylchlorosilane are added to a mixture of 85 g of 2-ethoxy-5-(3-methoxy-2-pyridyloxymethyl)-2-methyl-1,3-dioxolane in 500 ml of methylene chloride and the mixture is stirred for one hour at 20°-30°. Complete evaporation under reduced pressure yields crude 2-(2-acetoxy-3-chloro-propoxy)-3-methoxy-pyridine in the form of an oil, which is used without purification.
후처리
- customComplete evaporation under reduced pressure
출처 및 근거
- ORD 기록
- ord-7954d72259c94326a872eba2df1e1d41
- 출처 데이터셋
- uspto-grants-1981_04
- 특허 번호
- US04264599
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