Ammonium Chloride → 5-[(4-Chlorophenyl)sulfanyl]pyridin-2-amine
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:6][N:5]=1)([O-])=O.[Cl-].[NH4+]>[Fe]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:6][N:5]=1참가 물질
4
실험 절차
2-Nitro-5-(4-chlorophenylthio)pyridine (10.5 grams), ammonium chloride (50.0 grams), and powdered iron (30.0 grams) were reacted in the same procedures reported in Example 3. The reaction mixture was filtered hot solvents were removed. The product was extracted with ethyl acetate, washed with water, the ethyl acetate removed, and the product crystallized from ethyl acetate-hexanes, yield 4.5 grams, m.p. 157°-159° C.
후처리
- filtrationThe reaction mixture was filtered hot solvents
- customwere removed
- extractionThe product was extracted with ethyl acetate
- washwashed with water
- customthe ethyl acetate removed
- customthe product crystallized from ethyl acetate-hexanes, yield 4.5 grams, m.p. 157°-159° C.
출처 및 근거
- ORD 기록
- ord-2f8ea697d9d74a2d80506e9342fd4fca
- 출처 데이터셋
- uspto-grants-1981_04
- 특허 번호
- US04264605
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