Pyridine → HCID 57106850, 화합물

HRID 444528

반응식

HRID 444528 반응식
N1C=CC=CC=1.[CH:7]1([CH:10]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[C:11](Cl)=[O:12])[CH2:9][CH2:8]1.[F:21][C:22]1[CH:38]=[CH:37][C:25]([O:26][C:27]2[CH:28]=[C:29]([CH:34]=[CH:35][CH:36]=2)[CH:30]([OH:33])[C:31]#[N:32])=[CH:24][CH:23]=1>C1(C)C=CC=CC=1>[CH:7]1([CH:10]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[C:11]([O:33][CH:30]([C:31]#[N:32])[C:29]2[CH:34]=[CH:35][CH:36]=[C:27]([O:26][C:25]3[CH:37]=[CH:38][C:22]([F:21])=[CH:23][CH:24]=3)[CH:28]=2)=[O:12])[CH2:9][CH2:8]1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 103995133-(4-Fluorophenoxy)-alpha-cyanobenzyl alcoholHCID 15083505alpha-Cyclopropyl-4-chlorophenylacetyl chloride

생성물 1

HCID 57106850HCID 57106850, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매3회

실험 절차

With stirring, 1 g of pyridine in 3 ml of toluene and 2.3 g of α-cyclopropyl-4-chlorophenylacetyl chloride in 3 ml of toluene are added successively at 0° to 10° C. to a solution of 2.43 g of 3-(4-fluorophenoxy)-α-cyanobenzyl alcohol in 20 ml of toluene. After stirring for 10 hours at room temperature, the reaction mixture is washed with water, 2 N hydrochloric acid and 3% sodium bicarbonate solution. The organic layer is dried over sodium sulfate and the toluene is distilled off, affording the compound of the formula ##STR4## with a refractive index of nD20 =1.5880.

후처리

  1. stirringAfter stirring for 10 hours at room temperature
  2. washthe reaction mixture is washed with water, 2 N hydrochloric acid and 3% sodium bicarbonate solution
  3. dry with materialThe organic layer is dried over sodium sulfate
  4. distillationthe toluene is distilled off
  5. customaffording the compound of the formula ##STR4## with a refractive index of nD20 =1.5880

출처 및 근거

ORD 기록
ord-1c2ed2ec9e014e41813aafee7645fe09
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04264624

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