Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dioxane hydrochloride → (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| 반응물 | (S)-benzyl 2-(4-(tert-butoxycarbonylamino)phenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59396122 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (S)-benzyl 2-(4-aminophenylcarbamoyl)pyrrolidine-1-carboxylate | HCID 59396116 | 94.7% |
반응 단계
To a solution of the Product from Example 3A (0.245 g, 0.56 mmol) in dioxane (5 mL) was added 4M HCl dioxane (2.8 mL, 11.2 mol) and the mixture was stirred at ambient temperature for 17 hours. The mixture was concentrated and azeotroped with toluene to give a tan solid (0.18 g, 86%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541424B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-2fb70fcb6ee44d94841669e1f407e784 |
| 출처 메모 | uspto-grants-2013_09 |