Water → HCID 178443176, 화합물

HRID 444592노트

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HRID 444592 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[N:10]1[C:14](=[O:15])[CH2:13][C:12]([NH:16][C:17]2[CH:22]=[C:21]([NH:23][C:24](=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:20]=[CH:19][C:18]=2[Cl:39])=[N:11]1.C(=O)([O-])[O-].[K+].[K+].Cl.[CH2:47]([S:54]SC(=N)N)[C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1.O>C(O)C>[Cl:9][C:4]1[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[C:3]=1[N:10]1[C:14](=[O:15])[CH:13]([S:54][CH2:47][C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=2)[C:12]([NH:16][C:17]2[CH:22]=[C:21]([NH:23][C:24](=[O:38])[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH:20]=[CH:19][C:18]=2[Cl:39])=[N:11]1

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 23464086S-benzylthioisothiourea hydrochlorideHCID 178443172N-[4-chloro-3-[[5-oxo-1-(2,4,6-trichlorophenyl)-4H-pyrazol-3-yl]amino]phenyl]tetradecanamide

생성물 1

HCID 178443176HCID 178443176, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-(2,4,6-trichlorophenyl)-3-(2-chloro-5-tetradecanamidoanilino)-5-oxo-2-pyrazoline (21.4 g) was dissolved in 80% ethanol (ratio by volume of water:20%), and 2.42 g of anhydrous potassium carbonate was added thereto. The solution was refluxed with heating. 8.2 g of S-benzylthioisothiourea hydrochloride was added to the solution and the solution was vigorously stirred for 3 hours. After confirming the conclusion of the reaction by thin film chromatography, the reaction container was cooled with water. The formed crystals were separated by filtration and dissolved in 100 ml of hot ethanol. Insoluble materials were separated by filtration, and the filtrate was cooled. The resulting colorless crystals were Compound (1). The melting point was 182° to 185° C. and the yield was 12 g.

후처리

  1. temperatureThe solution was refluxed
  2. temperaturewith heating
  3. customthe conclusion of the reaction by thin film chromatography
  4. customThe formed crystals were separated by filtration
  5. dissolutiondissolved in 100 ml of hot ethanol
  6. customInsoluble materials were separated by filtration
  7. temperaturethe filtrate was cooled

출처 및 근거

ORD 기록
ord-1bce0b5d3aca4363bf329d0a4059a7a2
출처 데이터셋
uspto-grants-1981_04
특허 번호
US04264723

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