Ethanol → 5-Bromo-N-ethyl-2-nitroaniline

HRID 444880노트

반응식

HRID 444880 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4](F)[CH:3]=1.C[NH2:13].[CH3:14][CH2:15]O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([NH:13][CH2:15][CH3:14])[CH:3]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 6329MethylamineHCID 27833624-Bromo-2-fluoro-1-nitrobenzene

생성물 1

HCID 249029765-Bromo-N-ethyl-2-nitroaniline

반응 조건

온도
85 °C

실험 절차

A mixture of 4-bromo-2-fluoro-nitrobenzene (6 g, 27.3 mmol), methylamine (2M in MeOH, 34.1 mL, 68.2 mmol, 2.5 eq) and EtOH (80 mL) is stirred for 15 h at 85° C., allowed to cool and concentrated. The residue purified by trituration to afford 6 g of the title compound as an yellow solid: tR=5.13 min (System 1).

후처리

  1. temperatureto cool
  2. concentrationconcentrated
  3. customThe residue purified by trituration

출처 및 근거

ORD 기록
ord-460799fe68314f6a90788d9c15745ec7
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476268B2

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