4-Methylbenzaldehyde → N-(1H-indazol-5-yl)-2-(4-methylbenzyl)-2-azabicyclo[2.2.2]octan-4-amine

HRID 445133

반응식

HRID 445133 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]34[CH2:18][CH2:17][CH:14]([CH2:15][CH2:16]3)[NH:13][CH2:12]4)=[CH:7][CH:8]=2)[CH:3]=[N:2]1.[CH3:19][C:20]1[CH:27]=[CH:26][C:23]([CH:24]=O)=[CH:22][CH:21]=1>>[NH:1]1[C:9]2[C:4](=[CH:5][C:6]([NH:10][C:11]34[CH2:16][CH2:15][CH:14]([CH2:17][CH2:18]3)[N:13]([CH2:19][C:20]3[CH:27]=[CH:26][C:23]([CH3:24])=[CH:22][CH:21]=3)[CH2:12]4)=[CH:7][CH:8]=2)[CH:3]=[N:2]1

참가 물질

3

반응물 2

HCID 77254-MethylbenzaldehydeHCID 67234936N-(1H-indazol-5-yl)-2-azabicyclo[2.2.2]octan-4-amine

생성물 1

HCID 53247678N-(1H-indazol-5-yl)-2-(4-methylbenzyl)-2-azabicyclo[2.2.2]octan-4-amine

실험 절차

Reaction of Intermediate 26 with 4-methylbenzaldehyde affords the title compound.

출처 및 근거

ORD 기록
ord-5fa135ffb5f94c318cfa248020eb1208
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476295B2

연결된 노트

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