Sodium Cyanate → 1-Isopropyl-1-(4-methoxy-phenyl)-urea

HRID 445150노트

반응식

HRID 445150 반응식
[CH:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)([CH3:3])[CH3:2].[O-:13][C:14]#[N:15].[Na+]>C(O)(=O)C>[CH:1]([N:4]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][CH:6]=1)[C:14]([NH2:15])=[O:13])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 517096Sodium CyanateHCID 27594984-methoxy-N-(propan-2-yl)aniline

생성물 1

HCID 130988041-Isopropyl-1-(4-methoxy-phenyl)-urea

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

To a solution of 4.47 g (27.1 mmol) isopropyl-(4-methoxy-phenyl)-amine in 70 ml acetic acid are added in small portions 1.72 g (25.4 mmol) sodium cyanate while keeping the temperature below 15° C. by means of an ice bath. After stirring for 2 h at room temperature the acetic acid is evaporated and the residue is taken up in dichloromethane and washed with aqueous sodium hydroxide solution (1M). The organic phase is evaporated and the crude product is purified by recrystallization from dichloromethane/hexanes to yield 1-isopropyl-1-(4-methoxy-phenyl)-urea.

후처리

  1. customthe temperature below 15° C.
  2. customis evaporated
  3. washwashed with aqueous sodium hydroxide solution (1M)
  4. customThe organic phase is evaporated
  5. customthe crude product is purified by recrystallization from dichloromethane/hexanes

출처 및 근거

ORD 기록
ord-48fca9add93343c28be773acf4447825
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476286B2

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