Potassium Carbonate → (4-Isopropyl-phenyl)-{5-methoxy-2-[(pyridin-2-ylmethyl)-amino]-phenyl}-methanone

HRID 445157노트

반응식

HRID 445157 반응식
C(=O)([O-])[O-].[K+].[K+].Br.BrC[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][C:19]=1[C:26]([C:28]1[CH:33]=[CH:32][C:31]([CH:34]([CH3:36])[CH3:35])=[CH:30][CH:29]=1)=[O:27]>CC(C)=O.C(OCC)(=O)C>[CH:34]([C:31]1[CH:30]=[CH:29][C:28]([C:26]([C:19]2[CH:20]=[C:21]([O:24][CH3:25])[CH:22]=[CH:23][C:18]=2[NH:17][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[O:27])=[CH:33][CH:32]=1)([CH3:36])[CH3:35]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 129138592-(2-Bromoethyl)pyridine hydrobromideHCID 45139626(2-Amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone

생성물 1

HCID 60112811(4-Isopropyl-phenyl)-{5-methoxy-2-[(pyridin-2-ylmethyl)-amino]-phenyl}-methanone

시약·촉매·용매 2

HCID 180Acetone용매HCID 8857Ethyl Acetate용매

반응 조건

온도
90 °C

실험 절차

410 mg (2.97 mmol) potassium carbonate and 150 mg (0.59 mmol) 2-bromoethylpyridine hydrobromide are added to a solution of 160 mg (0.59 mmol) (2-amino-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone in 3 ml acetone. The reaction mixture is stirred for 2 days at 90° C., diluted with ethyl acetate and extracted with brine. The organic layer is dried and evaporated. After chromatography (hexane/ethyl acetate) the product is obtained as yellow oil.

후처리

  1. extractionextracted with brine
  2. customThe organic layer is dried
  3. customevaporated
  4. customAfter chromatography (hexane/ethyl acetate) the product is obtained as yellow oil

출처 및 근거

ORD 기록
ord-1435837fdae74f3696e73de0cb68cde5
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476286B2

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