Potassium Carbonate → 1-(2-hydroxy-2-phenyl-ethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one

HRID 445185

반응식

HRID 445185 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([O:20][CH2:21][C:22]#[CH:23])[CH:18]=3)[NH:13][C:12](=[O:24])[N:11]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[O:25]1[C:27]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:26]1.C(=O)([O-])[O-].[K+].[K+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.O1CCOCC1>[OH:25][CH:27]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:26][N:13]1[C:14]2[C:19](=[CH:18][C:17]([O:20][CH2:21][C:22]#[CH:23])=[CH:16][CH:15]=2)[C:10]([C:7]2[CH:6]=[CH:5][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:9][CH:8]=2)=[N:11][C:12]1=[O:24]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 14299145Epoxy-styreneHCID 592591374-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one

생성물 1

HCID 601127781-(2-hydroxy-2-phenyl-ethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one

시약·촉매·용매 2

HCID 66133Benzyl triethylammonium chloride촉매HCID 312751,4-Dioxane용매

반응 조건

온도
90 °C

실험 절차

A mixture of 2.00 g (6.28 mmol) 4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one, 0.72 ml (6.28 mmol) epoxy-styrene, 0.143 g (0.628 mmol) benzyl-triethylammonium chloride (TEBA), 0.086 g (0.628 mmol) potassium carbonate and 5 ml dioxane is heated at 90° C. for 18 h. Aqueous work up followed by chromatography on silica gives 1-(2-hydroxy-2-phenyl-ethyl)-4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazolin-2-one.

출처 및 근거

ORD 기록
ord-93e8e8faa5fb407c81a1a0371cbcaf11
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476286B2

연결된 노트

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