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Dimethyl Sulfone → 1-(2-(4-(6-Methoxy-2-(5-methylthiophen-2-yl)naphthalen-1-yloxy)phenoxy)ethyl)piperidine

HRID 445229
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반응식

HRID 445229 반응식
Br[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:12][CH3:13])[CH:8]=2)[C:3]=1[O:14][C:15]1[CH:29]=[CH:28][C:18]([O:19][CH2:20][CH2:21][N:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)=[CH:17][CH:16]=1.[CH3:30][C:31]1[S:35][C:34](B(O)O)=[CH:33][CH:32]=1.CS(C)(=O)=O>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:13][O:12][C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][CH:6]=1)[C:3]([O:14][C:15]1[CH:29]=[CH:28][C:18]([O:19][CH2:20][CH2:21][N:22]3[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]3)=[CH:17][CH:16]=1)=[C:2]([C:34]1[S:35][C:31]([CH3:30])=[CH:32][CH:33]=1)[CH:11]=[CH:10]2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6213Dimethyl SulfoneHCID 2734374(5-Methylthiophen-2-yl)boronic acidHCID 583385631-(2-(4-(2-Bromo-6-methoxynaphthalen-1-yloxy)phenoxy)ethyl)piperidine

생성물 1

HCID 583385551-(2-(4-(6-Methoxy-2-(5-methylthiophen-2-yl)naphthalen-1-yloxy)phenoxy)ethyl)piperidine

시약·촉매·용매 1

HCID 178418397
HCID 178418397, 화합물
촉매

실험 절차

To a 3-necked round bottom flask, add 1-(2-(4-(2-bromo-6-methoxynaphthalen-1-yloxy)phenoxy)ethyl)piperidine (25 mg, 75.9 μmol), 5-methylthiophen-2-ylboronic acid (20 mg, 140.86 μmol), tetrakis(triphenylphosphine)palladium (20 mg, 17.3 μmol), and dimethyl sulfone (DMSO) (2 mL). Purge the reaction vessel with nitrogen five times. Heat the mixture was at 100° C. for 6 hours, followed by 80° C. for 40 hours.

후처리

  1. customPurge the reaction vessel with nitrogen five times
  2. temperatureHeat the mixture
  3. waitfollowed by 80° C. for 40 hours

출처 및 근거

ORD 기록
ord-786571809ffb42dfb69a72ac02d300a0
출처 데이터셋
uspto-grants-2013_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08476300B2

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