Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline → (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | HCID 16640696 | — |
| 반응물 | Carbon dioxide methanol | HCID 21973728 | — |
| 생성물 | (R)-1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline | HCID 28293305 | — |
반응 단계
Enantiomers of 1-(4-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroisoquinoline (2.120 g, 7.46 mmol, racemic mixture) were separated using chiral SFC (Chiralcel AD-H (250×21 Mm), 45% methanol/CO2 (100 bar), 65 mL/min, 220 nm) to give the title compound as a light yellow solid. MS (ESI, positive ion) m/z: 278 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08476297B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-eb1ae6770acf47df85bdc8dca904749e |
| 출처 메모 | uspto-grants-2013_07 |