Pyridine → Carbamic acid, 4-pyridinyl-, 4-nitrophenyl ester

HRID 445276

반응식

HRID 445276 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.Cl[C:9]([O:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=1)=[O:10].N1C=CC=CC=1>C(Cl)Cl>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:9](=[O:10])[O:11][C:12]2[CH:13]=[CH:14][C:15]([N+:18]([O-:20])=[O:19])=[CH:16][CH:17]=2)=[CH:3][CH:4]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 17274-AminopyridineHCID 821294-Nitrophenyl chloroformate

생성물 1

HCID 10355188Carbamic acid, 4-pyridinyl-, 4-nitrophenyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-aminopyridine (1.97 g, 20.9 mmol) in DCM (75 mL) at 0° C. was added 4-nitrophenyl chloroformate (4.21 g, 20.9 mmol) and pyridine (1.7 mL, 20.9 mmol). Then, the mixture was stirred at RT overnight. The white precipitated was filtered off and washed with DCM (2×50 mL), and then dried in vacuo to give the title compound as a white solid, which was used in the next step without further purification. MS (ESI, positive ion) m/z: 260 (M+H).

후처리

  1. customThe white precipitated
  2. filtrationwas filtered off
  3. washwashed with DCM (2×50 mL)
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-016b120e0961490a95cef900c506ab88
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476297B2

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