4-(Trifluoromethyl)benzaldehyde → (R)-N-(4-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

HRID 445359노트

반응식

HRID 445359 반응식
[CH3:1][C:2]([S@:5]([NH2:7])=[O:6])([CH3:4])[CH3:3].[F:8][C:9]([F:19])([F:18])[C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][CH:11]=1>C(Cl)Cl>[F:8][C:9]([F:18])([F:19])[C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[N:7][S@@:5]([C:2]([CH3:4])([CH3:3])[CH3:1])=[O:6])=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 10964479tert-Butylsulfinamide, (R)-(+)-

생성물 1

HCID 68498575(R)-N-(4-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(R)-2-methylpropane-2-sulfinamide (31.6 g, 260 mmol), 4-(trifluoromethyl)-benzaldehyde (22.7 g, 130 mmol) and cupric sulfate (83.2 g, 521 mmol) were added to 300 mL DCM and the mixture was stirred for 36 h. The mixture was filtered through a pad of celite and the filtrate was evaporated and purified via silica plug filtration. (R)—N-(4-(trifluoromethyl)benzylidene)-2-methylpropane-2-sulfinamide was obtained as a white solid.

후처리

  1. filtrationThe mixture was filtered through a pad of celite
  2. customthe filtrate was evaporated
  3. filtrationpurified via silica plug filtration

출처 및 근거

ORD 기록
ord-831372cf1646424bbaf41d789a1a005b
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476297B2

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