Ethanol → 5-Bromo-N-methyl-3-nitropyridin-2-amine

HRID 445621

반응식

HRID 445621 반응식
[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5](Cl)=[N:6][CH:7]=1.[CH3:12][NH2:13].CCO>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[C:5]([NH:13][CH3:12])=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 6329MethylamineHCID 70194125-Bromo-2-chloro-3-nitropyridine

생성물 1

HCID 108681495-Bromo-N-methyl-3-nitropyridin-2-amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 5-bromo-2-chloro-3-nitropyridine (Matrix, Columbia, USA, 9.8 g, 41.3 mmol) in 250 ml THF was added 8 M methylamine in EtOH (Aldrich, Buchs, Switzerland, 12.9 ml, 103 mmol). The reaction mixture was stirred 1 h at rt then was quenched with 300 ml water. The precipite was filtered and the filtrate concentrated before being filtered again. The yellow solids were combined and dried to give the title compound as a yellow solid (HPLC: tR 3.13 min (Method A)).

후처리

  1. customthen was quenched with 300 ml water
  2. filtrationThe precipite was filtered
  3. concentrationthe filtrate concentrated
  4. filtrationbefore being filtered again
  5. customdried

출처 및 근거

ORD 기록
ord-a355d5361bce4509af81f3ec9290f393
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476294B2

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