2-(4-Amino-3-methyl-pyrazol-1-yl)-ethanol → 8-bromo-1-[1-(2-hydroxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

HRID 445666노트

반응식

HRID 445666 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[N:12]([CH3:23])[C:13](=[O:22])[N:14]([C:15]4[C:16]([CH3:21])=[N:17][N:18]([CH3:20])[CH:19]=4)[C:5]=3[C:4]=2[CH:3]=1.NC1C(C)=NN(C[CH2:31][OH:32])C=1>>[Br:1][C:2]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[N:12]([CH3:23])[C:13](=[O:22])[N:14]([C:15]4[C:16]([CH3:21])=[N:17][N:18]([CH2:20][CH2:31][OH:32])[CH:19]=4)[C:5]=3[C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 552846902-(4-Amino-3-methyl-pyrazol-1-yl)-ethanolHCID 596197398-Bromo-1-(1,3-dimethyl-1H-pyrazol-4-yl)-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

생성물 1

HCID 596199998-bromo-1-[1-(2-hydroxy-ethyl)-3-methyl-1H-pyrazol-4-yl]-3-methyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-one

실험 절차

Alternatively, the title compound was synthesized in a similar manner as described for intermediate A starting from 2-(4-amino-3-methyl-pyrazol-1-yl)-ethanol (Stage 103.1.2).

출처 및 근거

ORD 기록
ord-e7b6374fcb754346ab42df303911586b
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476294B2

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