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Ethanol → (3R,4S)-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-3-carboxylic acid

HRID 446004
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반응식

HRID 446004 반응식
C(O)C.[C:4]([O:8][C:9](=[O:39])[CH2:10][C@@:11]1([C:27]([O:29]CC2C=CC(OC)=CC=2)=[O:28])[C@H:15]([CH3:16])[CH2:14][N:13](C(OCC2C=CC=CC=2)=O)[CH2:12]1)([CH3:7])([CH3:6])[CH3:5]>[Pd].O>[C:4]([O:8][C:9](=[O:39])[CH2:10][C@@:11]1([C:27]([OH:29])=[O:28])[C@H:15]([CH3:16])[CH2:14][NH:13][CH2:12]1)([CH3:5])([CH3:6])[CH3:7]
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참가 물질

5

반응물 2

HCID 702EthanolHCID 712936671-benzyl 3-(4-methoxyphenyl)methyl (3R*,4S*)-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-1,3-dicarboxylate

생성물 1

HCID 71293641(3R,4S)-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-3-carboxylic acid수율 95.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 962Water용매

실험 절차

Ethanol (50 ml) and 10% Pd/C (500 mg) were added to 1-benzyl 3-(4-methoxyphenyl)methyl (3R*,4S*)-3-[2-(tert-butoxy)-2-oxoethyl]-4-methylpyrrolidine-1,3-dicarboxylate obtained in Example 2i (2.92 g, 5.87 mmol), followed by stirring at mom temperature for 38 hours and five minutes under a hydrogen atmosphere. Water (100 ml) was added to the reaction liquid, which was stirred and filtered. The filtrate was concentrated to give the title compound (1.37 g, yield: 95.9%).

후처리

  1. stirringwas stirred
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-7b61fd75c234459894e75159b808504c
출처 데이터셋
uspto-grants-2013_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08476301B2

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