Ethyl Acetate → tert-Butyl 4-[(3R,4S)-3-[2-(tert-butoxy)-2-oxoethyl]-1-{[2-chloro-6-(trifluoromethyl)phenyl]methyl}-4-methylpyrrolidin-3-amido]piperidine-1-carboxylate

반응식

Br[CH2:2][C:3]1[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=1[Cl:13].C(=O)([O-])[O-].[K+].[K+].[C:20]([O:24][C:25](=[O:49])[CH2:26][C@@:27]1([C:33]([NH:35][CH:36]2[CH2:41][CH2:40][N:39]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:38][CH2:37]2)=[O:34])[C@H:31]([CH3:32])[CH2:30][NH:29][CH2:28]1)([CH3:23])([CH3:22])[CH3:21].C(OCC)(=O)C>CN(C)C=O>[C:20]([O:24][C:25](=[O:49])[CH2:26][C@@:27]1([C:33]([NH:35][CH:36]2[CH2:41][CH2:40][N:39]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[CH2:38][CH2:37]2)=[O:34])[C@H:31]([CH3:32])[CH2:30][N:29]([CH2:2][C:3]2[C:8]([C:9]([F:12])([F:11])[F:10])=[CH:7][CH:6]=[CH:5][C:4]=2[Cl:13])[CH2:28]1)([CH3:23])([CH3:21])[CH3:22]