tert-Butyl 2-[(3R*,4S*)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate → tert-Butyl 2-[(3R*,4S*)-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

HRID 446030노트

반응식

HRID 446030 반응식
ClC1C=CC=C(Cl)C=1C[N:10]1[CH2:14][C@@H:13]([CH3:15])[C@@:12]([CH2:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])([C:16](=[O:30])[NH:17][CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:20][CH2:19]2)[CH2:11]1>[OH-].[Pd+2].[OH-].CO>[CH2:24]([N:21]1[CH2:20][CH2:19][CH:18]([NH:17][C:16]([C@:12]2([CH2:31][C:32]([O:34][C:35]([CH3:37])([CH3:36])[CH3:38])=[O:33])[C@H:13]([CH3:15])[CH2:14][NH:10][CH2:11]2)=[O:30])[CH2:23][CH2:22]1)[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]

참가 물질

4

반응물 1

HCID 71293842tert-Butyl 2-[(3R*,4S*)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

생성물 1

HCID 71293828tert-Butyl 2-[(3R*,4S*)-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate수율 100%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

Methanol (10 ml) and 20% palladium hydroxide (50 mg) were added to 250 mg of tert-butyl 2-[(3R*,4S*)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate obtained in Example 10h, followed by stirring at room temperature for two hours under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated to give the title compound (180 mg).

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-0805993024fb47208219682df3b1a16c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476301B2

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