Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Novoldiamine → N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Novoldiamine | HCID 78953 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Quinolinepropionic acid, 1,2,3,4-tetrahydro- | HCID 98707 | — |
| 반응물 | 2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborate | HCID 9857522 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-(5-(diethylamino)pentan-2-yl)-3-(3,4-dihydroquinolin-1(2H)-yl)propanamide | HCID 59237981 | — |
반응 단계
The procedure was carried out as described previously in step (b) of Example 8 with Compound 7 (1.9 g, 9.3 mmol), 2-succinimido-1,1,3,3-tetramethyluronium tetrafluoroborate (3.4 g, 11.2 mmol), N,N-diisopropyl ethylamine (3.4 mL, 19.5 mmol), 2-amino-5-diethylaminopentane (2.2 g, 13.9 mmol) and DMF (40 mL). Compound 10 was obtained (2.64 g) as a viscous liquid and used without any further purification. The structure of Compound 10 is given below:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08476443B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-7bc45000ea794bd4b07beb0e0210e1c1 |
| 출처 메모 | uspto-grants-2013_07 |