Piperidine → HCID 178448215, 화합물

HRID 446065

반응식

HRID 446065 반응식
[CH2:1]([Sn:5]([CH2:23][CH2:24][CH2:25][CH3:26])([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1[CH:7]=[C:8]([C:12]2[O:16][C:15]([CH:17]=O)=[CH:14][CH:13]=2)[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4].[NH:27]1[CH:31]=[C:30]([CH2:32][CH2:33][N:34]2[C:38](=[O:39])[CH2:37][NH:36][C:35]2=[S:40])[N:29]=[CH:28]1.N1CCCCC1>ClCCl>[NH:27]1[CH:31]=[C:30]([CH2:32][CH2:33][N:34]2[C:38](=[O:39])/[C:37](=[CH:17]/[C:15]3[O:16][C:12]([C:8]4[CH:9]=[CH:10][CH:11]=[C:6]([Sn:5]([CH2:1][CH2:2][CH2:3][CH3:4])([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:19][CH2:20][CH2:21][CH3:22])[CH:7]=4)=[CH:13][CH:14]=3)/[NH:36][C:35]2=[S:40])[N:29]=[CH:28]1

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 866753635-(3-(Tributylstannyl)phenyl)furan-2-carbaldehydeHCID 178516795HCID 178516795, 화합물

생성물 1

HCID 178448215HCID 178448215, 화합물수율 45.9%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

5-(3-(Tributylstannyl)phenyl)furan-2-carbaldehyde (65 mg, 0.14 mmol) synthesized by the same method as in Example 4 and 3-(2-(1H-imidazol-4-yl)ethyl)-2-thioxoimidazolidin-4-one (32 mg, 0.15 mmol) synthesized by the same method as in Example 3 were dissolved in dichloromethane (7 mL), piperidine (20 μL) was added thereto, and the mixture was stirred at room temperature (25° C.) overnight. After the reaction was completed the solvent was removed by evaporation under reduced pressure, and the residue was subjected to silica gel column chromatography using chloroform/methanol (9/1 (volume ratio)) as an eluent, to give labeling precursor 3 in a yield of 42 mg (yield 45.9%).

후처리

  1. customsynthesized by the same method as in Example 3
  2. customwas removed by evaporation under reduced pressure
  3. customto give labeling precursor 3 in a yield of 42 mg (yield 45.9%)

출처 및 근거

ORD 기록
ord-2e60ac7379c546d68975effa1316f929
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476449B2

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