2-(Benzylthio)-8-ethoxy-5,6-dihydroquinazoline → 2-(benzylthio)-6,7-dihydroquinazolin-8(5H)-one

HRID 44614

반응식

HRID 44614 반응식
[CH2:1]([S:8][C:9]1[N:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH:13]=[C:12]([O:19]CC)[C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)(=O)C.O>[CH2:1]([S:8][C:9]1[N:18]=[CH:17][C:16]2[CH2:15][CH2:14][CH2:13][C:12](=[O:19])[C:11]=2[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 574441122-(Benzylthio)-8-ethoxy-5,6-dihydroquinazoline

생성물 1

HCID 574441132-(benzylthio)-6,7-dihydroquinazolin-8(5H)-one수율 74%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

1.5 g (5 mmol) of 2-(benzylthio)-8-ethoxy-5,6-dihydroquinazoline were dissolved in 50 mL of acetic acid and 3 mL of water. The solution was stirred at refluxing temperature for 4 hours. The solvent was then removed under vacuum, the residue partitioned between dichloromethane and a NaHCO3 saturated solution. The organic layer was dried over anhydrous Na2SO4 and concentrated, giving 1.0 g (74% yield) of the title compound.

후처리

  1. temperatureat refluxing temperature for 4 hours
  2. customThe solvent was then removed under vacuum
  3. customthe residue partitioned between dichloromethane
  4. dry with materialThe organic layer was dried over anhydrous Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d27242909df5490d8cc0ba77ab659de0
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541429B2

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