Acetic Acid → Perfluorophenyl acetate

HRID 446179노트

반응식

HRID 446179 반응식
[C:1]([OH:4])(=[O:3])[CH3:2].[F:5][C:6]1[C:11](O)=[C:10]([F:13])[C:9]([F:14])=[C:8]([F:15])[C:7]=1[F:16].C1(N=C=NC2CCCCC2)CCCCC1>CCOC(C)=O>[F:5][C:6]1[C:11]([O:3][C:1](=[O:4])[CH3:2])=[C:10]([F:13])[C:9]([F:14])=[C:8]([F:15])[C:7]=1[F:16]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 10868DicyclohexylcarbodiimideHCID 13041Pentafluorophenol

생성물 1

HCID 87968Perfluorophenyl acetate

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a 0.40 M solution of acetic acid (46 μL, 0.800 mmol) in EtOAc (2.00 mL, filtered through activated alumina) were added pentafluorophenol (162 mg, 0.880 mmol) and 1,3-dicyclohexylcarbodiimide (182 mg, 0.88 mmol). The reaction mixture was stirred for 12 h at rt at which time it was filtered (washing with EtOAc) and concentrated. Ester 19 was used immediately without further purification.

후처리

  1. filtrationwas filtered
  2. wash(washing with EtOAc)
  3. concentrationconcentrated
  4. customEster 19 was used immediately without further purification

출처 및 근거

ORD 기록
ord-bbaa0589e0ef4f21b38aa3eec71002f4
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476451B2

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