Potassium Carbonate → 2-Cyano-6-benzyloxymethyl quinoline

HRID 446188

반응식

HRID 446188 반응식
[C:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8](O)[CH:9]=2)[N:4]=1)#[N:2].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:21][O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[C:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:21][O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:9]=2)[N:4]=1)#[N:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 137983Benzyl chloromethyl etherHCID 144295346-Hydroxyquinoline-2-carbonitrile

생성물 1

HCID 668385032-Cyano-6-benzyloxymethyl quinoline

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 2-cyano-6-hydroxyquinoline (100 mg) in 10 mL of acetone was added potassium carbonate (122 mg). After stirring at RT for three minutes, the solution was put on ice. Benzyl chloromethyl ether (122 μL) was added through a needle and the resultant solution was stirred on ice for 2 hours. The solvent was then removed under vacuum and the residue was purified by flash chromatography with dichloromethane. 157 mg was obtained.

후처리

  1. customThe solvent was then removed under vacuum
  2. customthe residue was purified by flash chromatography with dichloromethane
  3. custom157 mg was obtained

출처 및 근거

ORD 기록
ord-392a545e01d546d7b058c2fce200b8f5
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476450B2

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