Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbon tetrabromide → 4-(Bromomethyl)phenyl acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbon tetrabromide | HCID 11205 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 4-Acetoxybenzyl alcohol | HCID 95906 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(Bromomethyl)phenyl acetate | HCID 10998771 | 79% |
반응 단계
To the solution of 4-hydroxymethylphenol acetate (2.50 g, 15.0 mmol) and carbon tetrabromide (5.97 g, 18.0 mmol) in 40 ml of methylene chloride was added triphenylphosphine (4.73 g, 180 mmol) under nitrogen. The resultant mixture was stirred for 3 hours. The product was purified by flash chromatography using heptane/ethyl acetate (90/10-80/20) as eluent in a yield of 79%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08476450B2 |
| 출처 데이터셋 | uspto-grants-2013_07 |
| ORD ID | ord-fc733c6b446f4213ba233c61ef64153c |
| 출처 메모 | uspto-grants-2013_07 |