Carbon tetrabromide → 4-(Bromomethyl)phenyl acetate

HRID 446199

반응식

HRID 446199 반응식
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11]O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(Br)(Br)(Br)[Br:14].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][Br:14])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 959064-Acetoxybenzyl alcohol

생성물 1

HCID 109987714-(Bromomethyl)phenyl acetate수율 79%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the solution of 4-hydroxymethylphenol acetate (2.50 g, 15.0 mmol) and carbon tetrabromide (5.97 g, 18.0 mmol) in 40 ml of methylene chloride was added triphenylphosphine (4.73 g, 180 mmol) under nitrogen. The resultant mixture was stirred for 3 hours. The product was purified by flash chromatography using heptane/ethyl acetate (90/10-80/20) as eluent in a yield of 79%.

후처리

  1. customThe product was purified by flash chromatography

출처 및 근거

ORD 기록
ord-fc733c6b446f4213ba233c61ef64153c
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476450B2

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