Methanol → Methyl 4-amino-3-nitrobenzoate

HRID 446224

반응식

HRID 446224 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-:13])=[O:12].S(Cl)(Cl)=O.[CH3:18]O>>[CH3:18][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([NH2:1])=[C:3]([N+:11]([O-:13])=[O:12])[CH:4]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 74115Benzoic acid, 4-amino-3-nitro-

생성물 1

HCID 3941008Methyl 4-amino-3-nitrobenzoate수율 81%

실험 절차

To a mixture of 4-amino-3-nitro-benzoic acid (10.0 g, 54.9 mm0l) suspended in methanol (150 mL) was added thionyl chloride (3.99 mL, 54.9 mmol). The mixture was heated to reflux overnight, then cooled to room temperature and filtered. The solid recovered by filtration was rinsed with cold methanol and dried to give 8.68 g (81%) of 4-amino-3-nitro-benzoic acid methyl ester.

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux overnight
  3. filtrationfiltered
  4. filtrationThe solid recovered by filtration
  5. washwas rinsed with cold methanol
  6. customdried

출처 및 근거

ORD 기록
ord-082a2ee6ac3344899b1513bf4c1150ff
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476457B2

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