2,5-Dimethoxybenzoic acid → 5-Hydroxy-2-methoxybenzoic acid

HRID 446275

반응식

HRID 446275 반응식
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([O:12]C)=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]>S(=O)(=O)(O)O>[OH:12][C:9]1[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[C:4]([CH:8]=1)[C:5]([OH:7])=[O:6]

참가 물질

3

반응물 1

HCID 760272,5-Dimethoxybenzoic acid

생성물 1

HCID 184646075-Hydroxy-2-methoxybenzoic acid

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

A solution of 2,5-dimethoxybenzoic acid (10.0 g, 54.9 mmol) in 55 mL concentrated sulfuric acid was heated to 55 deg. C. for 48 h. The reaction was then poured into ice. A precipitate formed, and the mixture was allowed to stand overnight. The resulting crystals were collected by filtration and dried in vacuo. The material was further purified by silica gel chromatography to give 5-hydroxy-2-methoxybenzoic acid as a white solid. MS m/z=169.0 [M+1]+. Calc'd for C8H8O4: 168.15.

후처리

  1. additionThe reaction was then poured into ice
  2. customA precipitate formed
  3. waitto stand overnight
  4. filtrationThe resulting crystals were collected by filtration
  5. customdried in vacuo
  6. customThe material was further purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-32f3ba746ca24d6a953da6c7c2b7a84f
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476434B2

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