Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 44633생성일: 2026년 10월 24일
Iodine → 8-Iodo-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide
https://huagongshe.com/ko/reaction/44633
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Isoamyl Nitrite | HCID 8053 | — |
| 반응물 | Cesium iodide | HCID 24601 | — |
| 반응물 | Ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide | HCID 68936324 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 8-Iodo-1,4,4-trimethyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide | HCID 44232945 | — |
반응 단계
In a round bottom flask maintained under argon atmosphere, ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid methylamide (13.00 g, 45.400 mmol) was dissolved into anhydrous dimethoxyethane (800 mL); cesium iodide (11.795 g, 45.400 mmol), bisublimated iodine (5.761 g, 22.698 mmol), copper(I) iodide (2.594 g, 13.621 mmol), and iso-amyl nitrite (9.107 mL, 68.100 mmol) were added in that order and the mixture was heated to 70° C. for 22 hours.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08541429B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-1712e10069594564bdddcc990bb7193f |
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| 출처 메모 | uspto-grants-2013_09 |
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