Methanol → HCID 58168614, 화합물

HRID 446389

반응식

HRID 446389 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH2:9][CH2:10][CH2:11]O)[CH:6]=[CH:7][CH:8]=1.[C:13]([Si:17]([CH3:24])([CH3:23])[O:18][CH2:19]CC#C)([CH3:16])([CH3:15])[CH3:14].CO>N>[Si:17]([O:18][CH2:19][CH2:11][C:10]#[C:9][C:5]1[CH:4]=[C:3]([CH2:2][OH:1])[CH:8]=[CH:7][CH:6]=1)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:24])[CH3:23]

참가 물질

5

반응물 3

HCID 887MethanolHCID 4304567(But-3-yn-1-yloxy)(tert-butyl)dimethylsilaneHCID 552676803-(3-(Hydroxymethyl)phenyl)propan-1-ol

생성물 1

HCID 58168614HCID 58168614, 화합물

시약·촉매·용매 1

HCID 222Ammonia용매

실험 절차

Prepared by the method of Aromatic Intermediate 18, step a using tert-butyldimethyl(but-3-ynyloxy)silane (0.92 g) in place of tert-butyl dimethyl(prop-2-ynyloxy)silane. The preparative HPLC conditions were changed to XBridge™, Gradient: 75-99% methanol in 0.2% aqueous ammonia to avoid cleavage of the silyl protecting group. Yield 0.79 g.

출처 및 근거

ORD 기록
ord-85e26b7b53604333b61856bee59e2fbd
출처 데이터셋
uspto-grants-2013_07
특허 번호
US08476265B2

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