Ammonium Chloride → 4-(4-Tert-butylpiperazin-1-yl)aniline
반응식
[C:1]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[Cl-].[NH4+]>CO.O.[Fe]>[C:1]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:2])[CH3:3]참가 물질
6
실험 절차
To a solution of 840 mg (3.189 mmol) of 1-tert-butyl-4-(4-nitrophenyl)piperazine in 24 mL of methanol, 904 mg (16.9 mmol) of ammonium chloride dissolved in 6 mL of water and 552 mg (9.886 mmol) of iron were added. After 7 hours, the suspension was cooled and filtered. pH was adjusted to 10 through portionwise addition of Na2CO3 to the aqueous phase. Extraction with dichloromethane yielded 667 mg of the title amine.
후처리
- temperaturethe suspension was cooled
- filtrationfiltered
- additionpH was adjusted to 10 through portionwise addition of Na2CO3 to the aqueous phase
- extractionExtraction with dichloromethane
출처 및 근거
- ORD 기록
- ord-e7e685d6fe9e494f97c7dc5fcc2eda18
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08541429B2
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